A bill for an act removing psilocybin and psilocyn from the list of substances classified as schedule I controlled substances under Iowa's uniform controlled substances Act.

Iowa House File 351 (HF351) was a bill introduced on February 12, 2025, aiming to remove psilocybin and psilocyn from Iowa's list of Schedule I controlled substances. This reclassification would have acknowledged potential medical uses for these substances and reduced associated legal penalties. The bill was referred to the House Public Safety Committee but did not advance further, effectively dying in committee.

Supporters of HF351 argued that reclassifying psilocybin and psilocyn could facilitate research into their therapeutic benefits, particularly for mental health conditions like depression and PTSD. They pointed to emerging studies suggesting these substances can be effective treatments when used under medical supervision. Advocates also noted that decriminalization could reduce incarceration rates for non-violent drug offenses, aligning with broader criminal justice reform efforts.

Opponents of the bill expressed concerns about public safety and the potential for increased recreational use and abuse if psilocybin and psilocyn were removed from the Schedule I list. They argued that the long-term effects of these substances are not fully understood and that decriminalization could lead to unintended consequences, such as higher rates of substance misuse and associated social issues.